🔬 Introduction
Trialex – TZ Injection is a broad-spectrum Injection antibiotic that combines Ceftriaxone, a third-generation cephalosporin, with Tazobactam, a beta-lactamase inhibitor. This powerful combination enhances antibacterial effectiveness by preventing bacterial resistance, making it ideal for treating severe infections.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (Intravenous administration)
✔ Protein Binding: Ceftriaxone – 85-95%
✔ Half-life: Ceftriaxone – 6-9 hours
✔ Excretion: Biliary (~40%) & Renal (~60%)
🦠 Indications & Uses
🚑 Trialex – TZ Injection is prescribed for:
✔ Severe Respiratory Tract Infections – Pneumonia, Bronchitis
✔ Urinary Tract Infections (UTIs) – Pyelonephritis, Cystitis
✔ Skin & Soft Tissue Infections – Cellulitis, Abscesses
✔ Gynecological Infections – Pelvic Inflammatory Disease (PID)
✔ Intra-Abdominal Infections – Peritonitis, Appendicitis
✔ Bone & Joint Infections – Osteomyelitis
✔ Sepsis & Bacteremia – Life-threatening bloodstream infections
✔ Post-Surgical Infections – Hospital-acquired infections
💉 Dosage & Administration
✔ Route: Intravenous (IV) or Intramuscular (IM) Injection
✔ Recommended Dosage:
- Adults: 1-2 g Ceftriaxone once daily, with Tazobactam as per severity
- Children: 50-100 mg/kg/day in divided doses
- Dosage adjusted based on severity & kidney function
📌 Administration Guidelines:
- IV infusion over 30-60 minutes
- IM Injection deep into a large muscle (e.g., gluteus maximus)
- Dilute with appropriate solvent before administration
- Complete the full course for best results
⚙️ Mechanism of Action
✔ Ceftriaxone: Inhibits bacterial cell wall synthesis, leading to bacterial death (bactericidal action).
✔ Tazobactam: Inhibits beta-lactamase enzymes, preventing bacterial resistance and enhancing Ceftriaxone’s effectiveness.
🔬 Effective Against:
- Gram-positive & Gram-negative bacteria
- Beta-lactamase-producing strains
⚠️ Warnings & Precautions
❌ Allergy Alert: Avoid if allergic to cephalosporins or penicillins
❌ Kidney/Liver Disease: Dose adjustment required
❌ Severe Diarrhea Risk: Monitor for Clostridium difficile-associated colitis
❌ Pregnancy & Lactation: Use under medical supervision
🚨 Adverse Effects
✔ Common: Injection site pain, mild diarrhea, nausea, rash
✔ Serious (Rare): Anaphylaxis, severe diarrhea, blood disorders
⚡ Drug Interactions
⚡ Calcium-containing IV solutions: Risk of precipitation in neonates
⚡ Blood Thinners (Warfarin): May increase bleeding risk
⚡ Probenecid: Can delay antibiotic elimination
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Protect from light & moisture
📌 Use reconstituted solution immediately or as per stability guidelines
🏆 Conclusion
Trialex – TZ Injection is a powerful, dual-action Injection antibiotic that delivers superior protection against resistant infections. Its broad-spectrum coverage and beta-lactamase inhibition make it a preferred choice for hospitalized patients and severe infections.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Trialex – TZ Injection – Dual-Action Power for Severe Infections! 💉✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
