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Itrazest – 100 Capsules

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🔬 Introduction

Itrazest – 100 Tablets contains Itraconazole 100 mg, a triazole antifungal that works by inhibiting fungal cell membrane synthesis. It is widely used to treat systemic and superficial fungal infections with high efficacy and minimal resistance.

⚕️ Pharmacokinetics & Bioavailability

✔ Bioavailability: 55% (increases with food intake)
✔ Peak Plasma Levels: 3–4 hours after oral intake
✔ Half-life: 21 hours (steady-state achieved in 1-2 weeks)
✔ Metabolism: Liver (CYP3A4 enzyme)
✔ Excretion: Bile & Urine (Minimal Renal Excretion)

🦠 Indications & Uses

🚑 Itrazest – 100 Tablets is used for the treatment of:

✔ Fungal Skin Infections (Tinea corporis, Tinea cruris, Tinea pedis)
✔ Onychomycosis (Fungal Nail Infection)
✔ Oral & Esophageal Candidiasis
✔ Systemic Fungal Infections (Histoplasmosis, Blastomycosis, Aspergillosis, Candidiasis)
✔ Pityriasis Versicolor (Skin Discoloration due to Malassezia Fungus)

💊 Dosage & Administration

✔ Route: Oral Use
✔ Recommended Dosage:
📌 Dermatophytosis & Pityriasis Versicolor: 100 mg once daily for 15 days
📌 Onychomycosis: 200 mg once daily for 3 months OR Pulse Therapy (200 mg twice daily for 1 week per month for 3 months)
📌 Systemic Fungal Infections: 200–400 mg daily as per severity

📌 Administration Guidelines:

  • Take with food to improve absorption
  • Avoid antacids & proton pump inhibitors (PPIs) as they reduce absorption

⚙️ Mechanism of Action

✔ Itraconazole (Triazole Antifungal): Inhibits ergosterol synthesis, an essential component of fungal cell membranes, leading to cell death and fungal elimination.

🔬 Effective Against:

  • Dermatophytes (Tinea Infections)
  • Candida species (Oral, Esophageal, and Systemic Candidiasis)
  • Aspergillus species (Aspergillosis)
  • Histoplasma & Blastomyces (Deep Systemic Fungal Infections)

⚠️ Warnings & Precautions

❌ Avoid in pregnancy (Teratogenic risk)
❌ Not recommended in severe liver disease
❌ Caution in heart failure patients (May cause fluid retention)
❌ Avoid grapefruit juice (Increases drug levels and side effects)

🚨 Adverse Effects

✔ Common: Nausea, Abdominal Pain, Headache, Rash
✔ Rare (Serious): Liver Toxicity, Heart Failure, Severe Allergic Reactions

⚡ Drug Interactions

⚡ Statins (Simvastatin, Lovastatin): Increased risk of muscle toxicity
⚡ Proton Pump Inhibitors (Omeprazole, Pantoprazole): Reduced itraconazole absorption
⚡ Rifampicin & Phenytoin: Reduce Itraconazole levels (May require dose adjustment)
⚡ Warfarin & Oral Anticoagulants: Increased risk of bleeding

📦 Storage Conditions

📌 Store in a cool, dry place below 30°C
📌 Protect from moisture & direct sunlight
📌 Keep out of reach of children

🏆 Conclusion

Itrazest – 100 Tablets  is a highly effective antifungal therapy for superficial & systemic fungal infections. With its broad-spectrum coverage and high patient compliance, it ensures rapid and lasting fungal clearance.

✅ Trusted Pharmaceutical Company in India

Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.

🚀 Itrazest – 100 Tablets– Advanced Antifungal Protection for Faster Recovery! 💊✨

📞 Contact Us

📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences

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