🔬 Introduction
Itrazest – 200 Capsules contains Itraconazole 200 mg, a highly potent triazole antifungal that effectively treats systemic and superficial fungal infections. It works by inhibiting fungal cell membrane synthesis, ensuring rapid relief and long-term fungal eradication.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 55% (increases with food intake)
✔ Peak Plasma Levels: 3–4 hours after oral intake
✔ Half-life: 21 hours (steady-state achieved in 1-2 weeks)
✔ Metabolism: Liver (CYP3A4 enzyme)
✔ Excretion: Bile & Urine (Minimal Renal Excretion)
🦠 Indications & Uses
🚑 Itrazest – 200 Capsules is used for the treatment of:
✔ Onychomycosis (Fungal Nail Infection)
✔ Severe Dermatophytosis (Tinea corporis, Tinea cruris, Tinea pedis)
✔ Systemic Mycoses (Histoplasmosis, Blastomycosis, Aspergillosis, Candidiasis)
✔ Oral & Esophageal Candidiasis
✔ Pityriasis Versicolor (Skin Discoloration due to Malassezia Fungus)
💊 Dosage & Administration
✔ Route: Oral Use
✔ Recommended Dosage:
📌 Severe Dermatophytosis & Pityriasis Versicolor: 200 mg once daily for 15-30 days
📌 Onychomycosis: 200 mg twice daily for 1 week per month (Pulse Therapy) OR 200 mg once daily for 3 months
📌 Systemic Fungal Infections: 200–400 mg daily as per severity
📌 Administration Guidelines:
- Take with food to improve absorption
- Avoid antacids & proton pump inhibitors (PPIs) as they reduce absorption
⚙️ Mechanism of Action
✔ Itraconazole (Triazole Antifungal): Inhibits ergosterol synthesis, an essential component of fungal cell membranes, leading to cell death and fungal elimination.
🔬 Effective Against:
- Dermatophytes (Tinea Infections)
- Candida species (Oral, Esophageal, and Systemic Candidiasis)
- Aspergillus species (Aspergillosis)
- Histoplasma & Blastomyces (Deep Systemic Fungal Infections)
⚠️ Warnings & Precautions
❌ Avoid in pregnancy (Teratogenic risk)
❌ Not recommended in severe liver disease
❌ Caution in heart failure patients (May cause fluid retention)
❌ Avoid grapefruit juice (Increases drug levels and side effects)
🚨 Adverse Effects
✔ Common: Nausea, Abdominal Pain, Headache, Rash
✔ Rare (Serious): Liver Toxicity, Heart Failure, Severe Allergic Reactions
⚡ Drug Interactions
⚡ Statins (Simvastatin, Lovastatin): Increased risk of muscle toxicity
⚡ Proton Pump Inhibitors (Omeprazole, Pantoprazole): Reduced itraconazole absorption
⚡ Rifampicin & Phenytoin: Reduce Itraconazole levels (May require dose adjustment)
⚡ Warfarin & Oral Anticoagulants: Increased risk of bleeding
📦 Storage Conditions
📌 Store in a cool, dry place below 30°C
📌 Protect from moisture & direct sunlight
📌 Keep out of reach of children
🏆 Conclusion
Itrazest – 200 Capsules is a highly effective antifungal therapy for moderate to severe fungal infections. With broad-spectrum coverage and enhanced patient compliance, it ensures rapid and lasting fungal clearance.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Itrazest – 200 Capsules – High-Potency Antifungal for Fast & Effective Relief! 💊✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
