Ceftriaxone

• Ceftriaxone is a new semisynthetic cephalosporin with broad-spectrum in vitro activity and an unusually long serum half-life.
• It is a safe and effective antibiotic for therapy of serious bacterial infections.
• Offers tissue concentration much higher than MIC for many virulent pathogens.

Tazobactam

• Helps ceftriaxone in regaining sensitivity against resistant strains
• Payne et al. reported that tazobactam has greater β lactamases inhibitory activity than sulbactam.

Combination

• The combination of ceftriaxone and tazobactam in the ratio of 8:1 can be an effective treatment to combat extended spectrum beta-lactamase producing E. coli infections.