🔬 Introduction
Trialex – 1G Injection is a third-generation cephalosporin antibiotic used for the treatment of moderate to severe bacterial infections. Its broad-spectrum activity makes it effective against both Gram-positive and Gram-negative bacteria, ensuring high efficacy with once-daily dosing.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (Intravenous administration)
✔ Protein Binding: 85-95%
✔ Half-life: 6-9 hours
✔ Excretion: Biliary (~40%) & Renal (~60%)
🦠 Indications & Uses
🚑 Trialex – 1G Injection is prescribed for:
✔ Severe Respiratory Tract Infections – Pneumonia, Bronchitis
✔ Urinary Tract Infections (UTIs) – Pyelonephritis, Cystitis
✔ Skin & Soft Tissue Infections – Cellulitis, Abscesses
✔ Gynecological Infections – Pelvic Inflammatory Disease (PID)
✔ Bone & Joint Infections – Osteomyelitis
✔ Sepsis & Bacteremia – Life-threatening bloodstream infections
✔ Meningitis – Bacterial meningitis due to Neisseria meningitidis & Streptococcus pneumoniae
✔ Post-Surgical Infections – Hospital-acquired infections
✔ Typhoid Fever – Effective against Salmonella typhi
💉 Dosage & Administration
✔ Route: Intravenous (IV) or Intramuscular (IM) Injection
✔ Recommended Dosage:
- Adults & Adolescents: 1-2 g once daily
- Severe Infections: Up to 4 g/day in divided doses
- Children (>1 month): 50-100 mg/kg/day (max 4 g/day)
- Meningitis/Typhoid Fever: Higher doses may be required
📌 Administration Guidelines:
- IV infusion over 30-60 minutes
- IM Injection deep into a large muscle (e.g., gluteus maximus)
- Dilute with appropriate solvent before administration
- Complete the full course for best results
⚙️ Mechanism of Action
✔ Ceftriaxone: Inhibits bacterial cell wall synthesis, leading to bacterial death (bactericidal action).
🔬 Effective Against:
- Gram-positive & Gram-negative bacteria
- β-lactamase-producing strains
⚠️ Warnings & Precautions
❌ Allergy Alert: Avoid if allergic to cephalosporins or penicillins
❌ Renal & Liver Impairment: Dose adjustment required
❌ Severe Diarrhea Risk: Monitor for Clostridium difficile-associated colitis
❌ Neonates: Risk of calcium precipitation; avoid with calcium-containing IV solutions
🚨 Adverse Effects
✔ Common: Injectionection site pain, mild diarrhea, nausea, rash
✔ Serious (Rare): Anaphylaxis, severe diarrhea, blood disorders
⚡ Drug Interactions
⚡ Calcium-containing IV solutions: Risk of precipitation in neonates
⚡ Blood Thinners (Warfarin): May increase bleeding risk
⚡ Probenecid: Can delay antibiotic elimination
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Protect from light & moisture
📌 Use reconstituted solution immediately or as per stability guidelines
🏆 Conclusion
Trialex – 1G Injection is a highly effective broad-spectrum antibiotic for severe bacterial infections. With its once-daily dosing and excellent penetration into tissues, it is a preferred choice for serious infections.
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Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Trialex – 1G Injection – Potent Infection Control with Broad-Spectrum Coverage! 💉✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
