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Trialex – SB 375 Injection

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🔬 Introduction

Trialex – SB 375 Injection is a potent antibiotic combination containing Ceftriaxone, a third-generation cephalosporin, and Sulbactam, a β-lactamase inhibitor. This combination ensures broad-spectrum antibacterial action, making it highly effective against β-lactamase-producing bacteria.

⚕️ Pharmacokinetics & Bioavailability

✔ Bioavailability: 100% (IV administration)
✔ Protein Binding: Ceftriaxone – 85-95%
✔ Half-life: Ceftriaxone – 6-9 hours | Sulbactam – 1 hour
✔ Excretion: Renal (~60%) & Biliary (~40%)

🦠 Indications & Uses

🚑 Trialex – SB 375 Injection is used for the treatment of:

✔ Respiratory Infections – Pneumonia, Bronchitis
✔ Urinary Tract Infections (UTIs) – Pyelonephritis, Cystitis
✔ Skin & Soft Tissue Infections – Cellulitis, Abscesses
✔ Bone & Joint Infections – Osteomyelitis
✔ Abdominal Infections – Peritonitis, Intra-abdominal abscesses
✔ Gynecological Infections – Pelvic Inflammatory Disease (PID)
✔ Sepsis & Bacteremia – Bloodstream infections
✔ Typhoid Fever – Effective against Salmonella typhi
✔ Meningitis – Bacterial meningitis treatment

💉 Dosage & Administration

✔ Route: Intravenous (IV) or Intramuscular (IM) Injectionection
✔ Recommended Dosage:

  • Adults & Adolescents: 375 mg once or twice daily
  • Severe Infections: Up to 3 g/day in divided doses
  • Children (>1 month): 50-100 mg/kg/day (max 4 g/day)
  • Typhoid Fever: 20 mg/kg/day for 5-7 days

📌 Administration Guidelines:

  • IV infusion over 30-60 minutes
  • IM Injectionection deep into a large muscle (e.g., gluteus maximus)
  • Dilute with appropriate solvent before administration
  • Complete the full course for best results

⚙️ Mechanism of Action

✔ Ceftriaxone: Inhibits bacterial cell wall synthesis, leading to bacterial death (bactericidal action).
✔ Sulbactam: Inactivates β-lactamase enzymes, preventing bacterial resistance to ceftriaxone.

🔬 Effective Against:

  • Gram-positive & Gram-negative bacteria
  • β-lactamase-producing bacteria

⚠️ Warnings & Precautions

❌ Allergy Alert: Avoid if allergic to cephalosporins or penicillins
❌ Renal & Liver Impairment: Dose adjustment required
❌ Severe Diarrhea Risk: Monitor for Clostridium difficile-associated colitis
❌ Neonates: Risk of calcium precipitation; avoid with calcium-containing IV solutions

🚨 Adverse Effects

✔ Common: Injectionection site pain, mild diarrhea, nausea, rash
✔ Serious (Rare): Anaphylaxis, severe diarrhea, blood disorders

⚡ Drug Interactions

⚡ Calcium-containing IV solutions: Risk of precipitation in neonates
⚡ Blood Thinners (Warfarin): May increase bleeding risk
⚡ Probenecid: Can delay antibiotic elimination

📦 Storage Conditions

📌 Store in a cool, dry place below 25°C
📌 Protect from light & moisture
📌 Use reconstituted solution immediately or as per stability guidelines

🏆 Conclusion

Trialex – SB 375 Injection is an effective combination therapy designed to combat resistant bacterial infections. Its dual action makes it a preferred choice for severe infections requiring broad-spectrum coverage.

✅ Trusted Pharmaceutical Company in India

Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.

🚀 Trialex – SB 375 Injection – Enhanced Protection, Faster Recovery! 💉✨

📞 Contact Us

📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences

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