🔬 Introduction
Trialex – SB 750 Injection is a broad-spectrum antibiotic that combines Ceftriaxone, a third-generation cephalosporin, with Sulbactam, a β-lactamase inhibitor. This powerful formulation ensures effective treatment of severe bacterial infections, including those caused by β-lactamase-producing bacteria.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (IV administration)
✔ Protein Binding: Ceftriaxone – 85-95%
✔ Half-life: Ceftriaxone – 6-9 hours | Sulbactam – 1 hour
✔ Excretion: Renal (~60%) & Biliary (~40%)
🦠 Indications & Uses
🚑 Trialex – SB 750 Injection is used to treat:
✔ Respiratory Infections – Pneumonia, Bronchitis
✔ Urinary Tract Infections (UTIs) – Pyelonephritis, Cystitis
✔ Skin & Soft Tissue Infections – Cellulitis, Abscesses
✔ Bone & Joint Infections – Osteomyelitis
✔ Abdominal Infections – Peritonitis, Intra-abdominal abscesses
✔ Gynecological Infections – Pelvic Inflammatory Disease (PID)
✔ Sepsis & Bacteremia – Bloodstream infections
✔ Typhoid Fever – Effective against Salmonella typhi
✔ Meningitis – Bacterial meningitis prevention
💉 Dosage & Administration
✔ Route: Intravenous (IV) or Intramuscular (IM) Injectionection
✔ Recommended Dosage:
- Adults & Adolescents: 750 mg once or twice daily
- Severe Infections: Up to 3 g/day in divided doses
- Children (>1 month): 50-100 mg/kg/day (max 4 g/day)
- Typhoid Fever: 20 mg/kg/day for 5-7 days
📌 Administration Guidelines:
- IV infusion over 30-60 minutes
- IM Injectionection deep into a large muscle (e.g., gluteus maximus)
- Dilute with appropriate solvent before administration
- Complete the full course for best results
⚙️ Mechanism of Action
✔ Ceftriaxone: Inhibits bacterial cell wall synthesis, leading to bacterial death (bactericidal action).
✔ Sulbactam: Inactivates β-lactamase enzymes, preventing bacterial resistance to ceftriaxone.
🔬 Effective Against:
- Gram-positive & Gram-negative bacteria
- β-lactamase-producing bacteria
⚠️ Warnings & Precautions
❌ Allergy Alert: Avoid if allergic to cephalosporins or penicillins
❌ Renal & Liver Impairment: Dose adjustment required
❌ Severe Diarrhea Risk: Monitor for Clostridium difficile-associated colitis
❌ Neonates: Risk of calcium precipitation; avoid with calcium-containing IV solutions
🚨 Adverse Effects
✔ Common: Injectionection site pain, mild diarrhea, nausea, rash
✔ Serious (Rare): Anaphylaxis, severe diarrhea, blood disorders
⚡ Drug Interactions
⚡ Calcium-containing IV solutions: Risk of precipitation in neonates
⚡ Blood Thinners (Warfarin): May increase bleeding risk
⚡ Probenecid: Can delay antibiotic elimination
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Protect from light & moisture
📌 Use reconstituted solution immediately or as per stability guidelines
🏆 Conclusion
Trialex – SB 750 Injection is a powerful antibiotic combination that effectively combats resistant bacterial infections. Its dual mechanism makes it an ideal choice for severe infections where β-lactamase resistance is a concern.
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Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Trialex – SB 750 Injection – Dual Protection Against Infections! 💉✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
