🔬 Introduction
Trialex – SB 1.5gm Injection is a broad-spectrum combination antibiotic containing Ceftriaxone, a third-generation cephalosporin, and Sulbactam, a β-lactamase inhibitor. This powerful combination provides enhanced efficacy against β-lactamase-producing bacteria, ensuring superior infection control.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (Intravenous administration)
✔ Protein Binding: Ceftriaxone – 85-95%
✔ Half-life: Ceftriaxone – 6-9 hours | Sulbactam – 1 hour
✔ Excretion: Renal (~60%) & Biliary (~40%)
🦠 Indications & Uses
🚑 Trialex – SB 1.5gm Injection is prescribed for:
✔ Severe Respiratory Infections – Pneumonia, Bronchitis
✔ Urinary Tract Infections (UTIs) – Pyelonephritis, Cystitis
✔ Skin & Soft Tissue Infections – Cellulitis, Abscesses
✔ Bone & Joint Infections – Osteomyelitis
✔ Abdominal Infections – Peritonitis, Intra-abdominal abscesses
✔ Gynecological Infections – Pelvic Inflammatory Disease (PID)
✔ Sepsis & Bacteremia – Bloodstream infections
✔ Typhoid Fever – Effective against Salmonella typhi
✔ Meningitis – Bacterial meningitis prevention
💉 Dosage & Administration
✔ Route: Intravenous (IV) or Intramuscular (IM) Injectionection
✔ Recommended Dosage:
- Adults & Adolescents: 1.5 g once or twice daily
- Severe Infections: Up to 3 g/day in divided doses
- Children (>1 month): 50-100 mg/kg/day (max 4 g/day)
- Typhoid Fever: 20 mg/kg/day for 5-7 days
📌 Administration Guidelines:
- IV infusion over 30-60 minutes
- IM Injectionection deep into a large muscle (e.g., gluteus maximus)
- Dilute with appropriate solvent before administration
- Complete the full course for best results
⚙️ Mechanism of Action
✔ Ceftriaxone: Inhibits bacterial cell wall synthesis, leading to bacterial death (bactericidal action).
✔ Sulbactam: Inactivates β-lactamase enzymes, preventing bacterial resistance to ceftriaxone.
🔬 Effective Against:
- Gram-positive & Gram-negative bacteria
- β-lactamase-producing bacteria
⚠️ Warnings & Precautions
❌ Allergy Alert: Avoid if allergic to cephalosporins or penicillins
❌ Renal & Liver Impairment: Dose adjustment required
❌ Severe Diarrhea Risk: Monitor for Clostridium difficile-associated colitis
❌ Neonates: Risk of calcium precipitation; avoid with calcium-containing IV solutions
🚨 Adverse Effects
✔ Common: Injectionection site pain, mild diarrhea, nausea, rash
✔ Serious (Rare): Anaphylaxis, severe diarrhea, blood disorders
⚡ Drug Interactions
⚡ Calcium-containing IV solutions: Risk of precipitation in neonates
⚡ Blood Thinners (Warfarin): May increase bleeding risk
⚡ Probenecid: Can delay antibiotic elimination
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Protect from light & moisture
📌 Use reconstituted solution immediately or as per stability guidelines
🏆 Conclusion
Trialex – SB 1.5gm Injection offers a potent combination of Ceftriaxone and Sulbactam, making it an excellent choice for treating severe infections resistant to standard antibiotics.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Trialex – SB 1.5gm Injection – Dual Power for Superior Infection Control! 💉✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
