Meronorm 500 Injection is a broad-spectrum carbapenem antibiotic used to treat serious bacterial infections. Meropenem is a beta-lactam antibiotic that effectively targets Gram-positive, Gram-negative, and anaerobic bacteria. It is highly stable against beta-lactamase enzymes, making it a strong choice for resistant infections.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (IV administration)
✔ Peak Plasma Concentration: Within 1 hour of IV infusion
✔ Protein Binding: ~2%
✔ Half-life: ~1 hour
✔ Excretion: Primarily via urine (~70% unchanged)
🦠 Indications & Uses
🚑 Meronorm 500 Injection is prescribed for:
✔ Complicated Intra-Abdominal Infections
✔ Severe Pneumonia (Including Hospital-Acquired & Ventilator-Associated Pneumonia)
✔ Urinary Tract Infections (UTI) & Pyelonephritis
✔ Skin & Soft Tissue Infections
✔ Bacterial Meningitis
✔ Sepsis & Bloodstream Infections
💉 Dosage & Administration
✔ Adult Dose: 500 mg to 1 g every 8 hours, depending on the severity of infection
✔ Pediatric Dose (≥3 months): 10–20 mg/kg every 8 hours
✔ Severe Infections: Higher doses may be required under medical supervision
✔ Route: Intravenous (IV) injection or infusion
📌 Administration Guidelines:
- Administer slow IV injection over 3-5 minutes
- Can also be given via IV infusion over 15-30 minutes
⚙️ Mechanism of Action
✔ Meropenem: Inhibits bacterial cell wall synthesis, leading to bacterial cell death (bactericidal effect)
✔ Broad-Spectrum Action: Covers Gram-positive, Gram-negative, and anaerobic bacteria
✔ Effective Against: E. coli, Klebsiella, Pseudomonas aeruginosa, Enterobacter, Streptococcus pneumoniae, Bacteroides fragilis
⚠️ Warnings & Precautions
❌ Renal Impairment: Dose adjustment required in patients with kidney dysfunction
❌ Hypersensitivity: Avoid in patients allergic to beta-lactam antibiotics
❌ Seizure Risk: Use with caution in patients with CNS disorders
❌ Superinfection Risk: Prolonged use may lead to fungal or resistant bacterial infections
🚨 Adverse Effects
✔ Common: Nausea, vomiting, diarrhea, headache, rash
✔ Serious: Seizures, Clostridium difficile infection, anaphylaxis
⚡ Drug Interactions
⚡ Valproic Acid: Meropenem reduces valproate levels, increasing seizure risk
⚡ Probenecid: Increases meropenem levels by reducing renal clearance
⚡ Anticoagulants (Warfarin): May increase bleeding risk
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Use reconstituted solution immediately or within the recommended time
🏆 Conclusion
Meronorm 500 Injection (Meropenem 500 mg + Sodium 45.1 mg) is a highly effective carbapenem antibiotic used in the treatment of life-threatening bacterial infections. It provides broad-spectrum coverage, making it a preferred choice in hospitals for critically ill patients.
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🚀 Meronorm 500 – Powerful Protection Against Severe Infections! 💊💪
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