🔬 Introduction
Meronorm 1000 Injection is a broad-spectrum carbapenem antibiotic designed for the treatment of severe bacterial infections. Meropenem is a potent beta-lactam antibiotic that effectively combats Gram-positive, Gram-negative, and anaerobic bacteria. It is highly resistant to beta-lactamase enzymes, making it an excellent choice for multi-drug resistant infections.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (IV administration)
✔ Peak Plasma Concentration: Within 1 hour of IV infusion
✔ Protein Binding: ~2%
✔ Half-life: ~1 hour
✔ Excretion: Primarily via urine (~70% unchanged)
🦠 Indications & Uses
🚑 Meronorm 1000 Injection is prescribed for:
✔ Complicated Intra-Abdominal Infections
✔ Severe Pneumonia (Including Hospital-Acquired & Ventilator-Associated Pneumonia)
✔ Complicated Urinary Tract Infections (UTI) & Pyelonephritis
✔ Skin & Soft Tissue Infections
✔ Bacterial Meningitis
✔ Sepsis & Bloodstream Infections
💉 Dosage & Administration
✔ Adult Dose: 1 g (1000 mg) every 8 hours, depending on infection severity
✔ Pediatric Dose (≥3 months): 20 mg/kg every 8 hours
✔ Severe Infections: Higher doses may be required under medical supervision
✔ Route: Intravenous (IV) injection or infusion
📌 Administration Guidelines:
- Administer slow IV injection over 3-5 minutes
- Can also be given via IV infusion over 15-30 minutes
⚙️ Mechanism of Action
✔ Meropenem: Inhibits bacterial cell wall synthesis, leading to bacterial cell death (bactericidal effect)
✔ Broad-Spectrum Action: Covers Gram-positive, Gram-negative, and anaerobic bacteria
✔ Effective Against: E. coli, Klebsiella, Pseudomonas aeruginosa, Enterobacter, Streptococcus pneumoniae, Bacteroides fragilis
⚠️ Warnings & Precautions
❌ Renal Impairment: Dose adjustment required in patients with kidney dysfunction
❌ Hypersensitivity: Avoid in patients allergic to beta-lactam antibiotics
❌ Seizure Risk: Use with caution in patients with CNS disorders
❌ Superinfection Risk: Prolonged use may lead to fungal or resistant bacterial infections
🚨 Adverse Effects
✔ Common: Nausea, vomiting, diarrhea, headache, rash
✔ Serious: Seizures, Clostridium difficile infection, anaphylaxis
⚡ Drug Interactions
⚡ Valproic Acid: Meropenem reduces valproate levels, increasing seizure risk
⚡ Probenecid: Increases meropenem levels by reducing renal clearance
⚡ Anticoagulants (Warfarin): May increase bleeding risk
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Use reconstituted solution immediately or within the recommended time
🏆 Conclusion
Meronorm 1000 Injection (Meropenem 1000 mg + Sodium 90.2 mg) is a highly potent carbapenem antibiotic used for the treatment of life-threatening bacterial infections. It provides broad-spectrum coverage, making it a gold-standard choice in hospitals for critically ill patients.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Meronorm 1000 – High-Potency Protection Against Severe Infections! 💊💪
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
