💉 Bactaz-P Injection – Broad-Spectrum IV Antibiotic by Minova Life Sciences

🧬 Introduction

Bactaz-P is a powerful injectable antibiotic combination offered by Minova Life Sciences, combining:

• Piperacillin Sodium 4000 mg + Tazobactam Sodium 500 mg (Bactaz-P 4.5 Injection)

• Piperacillin Sodium 1000 mg + Tazobactam Sodium 125 mg (Bactaz-P 1.125 Injection)

This beta-lactam/beta-lactamase inhibitor combination is used for treating severe systemic infections caused by multidrug-resistant bacteria.

⚙️ Pharmacokinetics & Bioavailability

• Piperacillin: Extended-spectrum penicillin, bactericidal

• Tazobactam: Inhibits beta-lactamases, enhances Piperacillin efficacy

• Administration: Intravenous (IV)

• Peak Plasma Concentration: Within 30 minutes post-infusion

• Half-Life: ~1 hour

• Excretion: Primarily renal (urine)

📌 Indications & Uses

Bactaz-P is indicated for:

• Intra-abdominal infections

• Pneumonia (including hospital-acquired)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Septicemia

• Bone and joint infections

• Gynecological infections

• Febrile neutropenia

🕒 Dosage & Administration

✅ Bactaz-P 4.5 Injection

• Adults: 4.5g IV every 6–8 hours

• Adjust dosage in renal impairment

✅ Bactaz-P 1.125 Injection

• Used in moderate infections or based on patient body weight

• Often prescribed for pediatrics or in milder clinical cases

⚠️ Must be administered by healthcare professionals under sterile conditions.

❌ Contraindications

• Hypersensitivity to penicillins, cephalosporins, or beta-lactam antibiotics

• History of severe allergic reaction (e.g., anaphylaxis)

⚠️ Warnings & Precautions

• Use with caution in patients with renal insufficiency

• Monitor for C. difficile-associated diarrhea

• Can cause electrolyte disturbances

• May interfere with certain lab tests (e.g., glucose)

❗ Adverse Effects

Common:

• Nausea, vomiting

• Rash or local injection site reaction

• Diarrhea

Rare but serious:

• Thrombocytopenia

• Anaphylaxis

• Neutropenia

• Seizures (especially in renal failure)

💊 Drug Interactions

• Aminoglycosides: Avoid mixing in same syringe/line

• Probenecid: Increases Piperacillin levels

• Oral anticoagulants: Monitor INR/PT

• Methotrexate: Delayed clearance

🧊 Storage Conditions

• Store between 2°C to 8°C

• Protect from light and moisture

• Use immediately after reconstitution

✅ Conclusion

Bactaz-P Injection is a powerful, life-saving treatment option for hospital settings and critical care. With its broad-spectrum coverage and proven efficacy against resistant organisms, it is a cornerstone antibiotic for serious infections.

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