Histacold Drops / Junior Suspension
Rapid Relief from Allergic Cold & Congestion
COMPOSITION
Phenylephrine HCL 2.5 mg + Chlorpheniramine maleate 1 mg + Paracetamol
INDICATION
- Nasal and sinus congestion.
- Upper respiratory tract infections.
- Sinus pain and headache.
- Sinusitis
- Tonsillitis
- Otitis media
Histacold Drops / Junior Suspension
Drug Class: Sympathomimetic agent/ decongestant
- Phenylephrine is a direct-acting sympathomimetic amine that functions as an alpha-1 adrenergic agonist.
- Phenylephrine is a sympathomimetic primarily used as a systemic nasal decongestant.
Alleviates blocked or stuffy nose:
- Responsible for the activation of postjunctional alpha-adrenergic receptors in the nasal mucosa by,
- Distinct binding of the sympathomimetic agent to the binding site of the receptor, or
- The enhanced release of norepinephrine leads to vasoconstriction.
Chlorpheniramine Maleate
Drug Class: Antihistamines
- Also known as chlorphenamine (CPM), is a potent alkylamine first-generation H1 antihistamine.
- One of the most often recommended and used 1st generation, antihistaminic agents.
The anti-allergic and anti-inflammatory action of CPM:
- It competitively binds to the H1 receptors of the vascular tunica medius in the nasal mucosa to prevent the histamine vasoreactive response.
- Its antihistaminic action is translated to its anti-allergic & anti-inflammatory action in the nasal mucosa.
- Its anti-cholinergic action is responsible for the decrease in nasal discharge, which is infective, hence it controls the symptoms of Allergic Rhinitis.
COMBINATION:
- A combination of Phenylephrine 2.5 mg and Chlorpheniramine maleate 1 mg provides optimum symptomatic relief and is safe for the treatment of allergic rhinitis in infants.
