🔬 Introduction
Matchfix-OF Tablets combine the power of Cefixime (a third-generation cephalosporin) and Ofloxacin (a fluoroquinolone), offering a broad-spectrum antibiotic solution for bacterial infections. This combination is highly effective against Gram-positive and Gram-negative bacteria, making it a preferred choice for respiratory, urinary, and gastrointestinal infections.
⚕️ Pharmacokinetics & Bioavailability
✔ Cefixime Bioavailability: ~50% (oral absorption)
✔ Ofloxacin Bioavailability: ~95% (oral absorption)
✔ Peak Plasma Concentration: Within 2-4 hours of oral administration
✔ Protein Binding: Cefixime – 65%, Ofloxacin – 32%
✔ Half-life: Cefixime – ~3-4 hours, Ofloxacin – ~5-6 hours
✔ Excretion: Primarily via urine (~50-70%)
🦠 Indications & Uses
🚑 Matchfix-OF Tablets are prescribed for:
✔ Respiratory Tract Infections (RTIs) – Bronchitis, Pneumonia, Pharyngitis
✔ Urinary Tract Infections (UTIs) & Cystitis
✔ Typhoid Fever & Gastrointestinal Infections
✔ Skin & Soft Tissue Infections
✔ Sexually Transmitted Infections (STIs) like Gonorrhea
💊 Dosage & Administration
✔ Adult Dose: 1 tablet twice daily (every 12 hours) or as prescribed
✔ Pediatric Dose: Not recommended for children under 12 years
✔ Route: Oral administration
📌 Administration Guidelines:
- Take with or without food
- Swallow whole with a glass of water
- Complete the full course to prevent antibiotic resistance
⚙️ Mechanism of Action
✔ Cefixime: Inhibits bacterial cell wall synthesis, causing bacterial death (bactericidal effect)
✔ Ofloxacin: Inhibits bacterial DNA gyrase, preventing bacterial replication (bactericidal effect)
✔ Broad-Spectrum Action: Effective against E. coli, Klebsiella, Salmonella, Streptococcus, Staphylococcus, Pseudomonas
⚠️ Warnings & Precautions
❌ Kidney Impairment: Dose adjustment may be required
❌ Hypersensitivity: Avoid in patients allergic to cephalosporins or fluoroquinolones
❌ Tendon Rupture Risk: Use cautiously in elderly patients
❌ Superinfection Risk: Prolonged use may lead to fungal or resistant bacterial infections
🚨 Adverse Effects
✔ Common: Nausea, vomiting, diarrhea, headache, dizziness
✔ Serious: Allergic reactions, tendon rupture, Clostridium difficile infection
⚡ Drug Interactions
⚡ Antacids (Magnesium/Aluminum): Reduce absorption of Ofloxacin
⚡ Blood Thinners (Warfarin): Increased risk of bleeding
⚡ Probenecid: May increase Cefixime levels
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Keep away from direct sunlight and moisture
🏆 Conclusion
Matchfix-OF Tablets (Cefixime 200 mg + Ofloxacin 200 mg) provide a potent dual-action approach to treating a wide range of bacterial infections. This broad-spectrum antibiotic ensures faster recovery and effective bacterial eradication.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Matchfix-OF – Dual Action Formula for Faster Infection Relief! 💊💪
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
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