🔬 Introduction
Itrazest – SB 130 Capsules is a highly advanced antifungal medication containing Itraconazole 130 mg with Supra Bioavailability, ensuring faster absorption and enhanced therapeutic action. This formulation is twice as potent as conventional Itraconazole, providing better efficacy in treating fungal infections.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: Higher than conventional Itraconazole (Supra Bioavailable Formulation)
✔ Peak Plasma Levels: Within 2–3 hours of administration
✔ Half-life: 21–30 hours (Long-lasting effect)
✔ Metabolism: Hepatic (CYP3A4 pathway)
✔ Excretion: Primarily through bile & feces (Minimal renal clearance)
🦠 Indications & Uses
🚑 Itrazest – SB 130 Capsules is used for the treatment of:
✔ Dermatophytosis (Tinea corporis, Tinea cruris, Tinea pedis)
✔ Onychomycosis (Fungal Nail Infection)
✔ Pityriasis Versicolor (Fungal Discoloration of the Skin)
✔ Oral & Esophageal Candidiasis
✔ Systemic Mycoses (Histoplasmosis, Blastomycosis, Aspergillosis, Candidiasis, Cryptococcosis)
💊 Dosage & Administration
✔ Route: Oral Use
✔ Recommended Dosage:
📌 Mild to Moderate Skin & Nail Infections: 130 mg once daily for 2–4 weeks
📌 Severe Dermatophytosis: 260 mg (2 capsules) once daily for 4–6 weeks
📌 Onychomycosis (Pulse Therapy): 260 mg twice daily for 1 week per month, continued for 3 months
📌 Systemic Fungal Infections: 260–390 mg daily depending on severity
📌 Administration Guidelines:
- Take with food to enhance absorption
- Avoid antacids & proton pump inhibitors (PPIs) for optimal drug efficacy
⚙️ Mechanism of Action
✔ Itraconazole (Supra Bioavailable Formulation): Inhibits ergosterol synthesis, leading to fungal cell membrane disruption and fungal death.
🔬 Effective Against:
- Dermatophytes (Tinea Infections)
- Candida species (Oral, Esophageal, and Systemic Candidiasis)
- Aspergillus species (Aspergillosis)
- Histoplasma & Blastomyces (Deep Systemic Fungal Infections)
⚠️ Warnings & Precautions
❌ Not recommended in pregnancy (Teratogenic risk)
❌ Caution in liver disease (Risk of hepatotoxicity)
❌ Avoid in patients with congestive heart failure (May cause fluid retention)
❌ Avoid grapefruit juice (Increases drug levels and toxicity risk)
🚨 Adverse Effects
✔ Common: Nausea, Vomiting, Headache, Abdominal Pain
✔ Rare (Serious): Hepatotoxicity, Heart Failure, Hypersensitivity Reactions
⚡ Drug Interactions
⚡ Statins (Simvastatin, Lovastatin): Increased risk of muscle toxicity
⚡ Proton Pump Inhibitors (Omeprazole, Pantoprazole): Reduce Itraconazole absorption
⚡ Rifampicin & Phenytoin: Decrease Itraconazole plasma levels
⚡ Warfarin & Oral Anticoagulants: Increased risk of bleeding complications
📦 Storage Conditions
📌 Store in a cool, dry place below 30°C
📌 Protect from moisture & direct sunlight
📌 Keep out of reach of children
🏆 Conclusion
Itrazest – SB 130 Capsules is an advanced antifungal solution with superior absorption and enhanced bioavailability, ensuring faster and more effective treatment of fungal infections.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Itrazest – SB 130 Capsules – Enhanced Absorption, Maximum Antifungal Potency! 💊✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
