🔬 Introduction
Itrazest – SB 65 Caps. contains Itraconazole 65 mg with Supra Bioavailability, making it a highly potent and fast-acting antifungal formulation. It is specifically designed to maximize absorption and efficacy, ensuring better therapeutic outcomes in treating various fungal infections.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: Higher than conventional Itraconazole (Supra Bioavailability Formulation)
✔ Peak Plasma Levels: Within 2–3 hours of oral administration
✔ Half-life: 21–30 hours (Long-lasting action)
✔ Metabolism: Liver (CYP3A4 enzyme pathway)
✔ Excretion: Primarily via bile & feces (Minimal renal excretion)
🦠 Indications & Uses
🚑 Itrazest – SB 65 Caps. is used for the treatment of:
✔ Dermatophytosis (Fungal Skin Infections – Tinea corporis, Tinea cruris, Tinea pedis)
✔ Onychomycosis (Fungal Nail Infection)
✔ Pityriasis Versicolor (Discoloration of Skin due to Malassezia Fungus)
✔ Oral & Esophageal Candidiasis
✔ Systemic Mycoses (Histoplasmosis, Blastomycosis, Aspergillosis, Candidiasis)
💊 Dosage & Administration
✔ Route: Oral Use
✔ Recommended Dosage:
📌 Mild to Moderate Skin & Nail Fungal Infections: 65 mg once daily for 2–4 weeks
📌 Severe Dermatophytosis: 130 mg (2 capsules) once daily for 4–6 weeks
📌 Onychomycosis (Pulse Therapy): 130 mg twice daily for 1 week per month, continued for 3 months
📌 Systemic Fungal Infections: 130–195 mg daily depending on severity
📌 Administration Guidelines:
- Take with food to enhance absorption
- Avoid antacids and proton pump inhibitors (PPIs) for optimal drug efficacy
⚙️ Mechanism of Action
✔ Itraconazole (Enhanced Supra Bioavailability Formulation): Inhibits ergosterol synthesis, disrupting fungal cell membrane integrity, leading to cell death and fungal clearance.
🔬 Effective Against:
- Dermatophytes (Tinea Infections)
- Candida species (Oral, Esophageal, and Systemic Candidiasis)
- Aspergillus species (Aspergillosis)
- Histoplasma & Blastomyces (Deep Systemic Fungal Infections)
⚠️ Warnings & Precautions
❌ Not recommended in pregnancy (Teratogenic risk)
❌ Caution in severe liver disease
❌ Avoid in patients with congestive heart failure (May cause fluid retention)
❌ Avoid grapefruit juice (Increases drug levels and risk of toxicity)
🚨 Adverse Effects
✔ Common: Nausea, Vomiting, Abdominal Pain, Headache
✔ Rare (Serious): Hepatotoxicity, Heart Failure, Hypersensitivity Reactions
⚡ Drug Interactions
⚡ Statins (Simvastatin, Lovastatin): Increased risk of muscle toxicity
⚡ Proton Pump Inhibitors (Omeprazole, Pantoprazole): Reduce Itraconazole absorption
⚡ Rifampicin & Phenytoin: Decrease Itraconazole plasma levels
⚡ Warfarin & Oral Anticoagulants: Increased risk of bleeding complications
📦 Storage Conditions
📌 Store in a cool, dry place below 30°C
📌 Protect from moisture & direct sunlight
📌 Keep out of reach of children
🏆 Conclusion
Itrazest – SB 65 Capsules offers an advanced antifungal solution with supra bioavailability, ensuring faster absorption, higher efficacy, and better patient compliance. Its broad-spectrum antifungal action makes it the ideal choice for treating skin, nail, and systemic fungal infections.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Itrazest – SB 65 Capsules – Advanced Antifungal with Supra Bioavailability for Maximum Efficacy! 💊✨
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
