Co: Drotaverine HCL IP: 80mg + Mefenamic Acid IP: 250mg
🔬 Introduction
Drotaflam-MF Tablets combine two powerful agents—Drotaverine Hydrochloride and Mefenamic Acid—for fast relief from abdominal pain, menstrual cramps, and spasmodic conditions. This formulation is ideal for managing smooth muscle spasms and inflammatory pain, commonly used in gynecological, gastrointestinal, and urinary tract-related disorders.
⚙️ Mechanism of Action
⭐ Drotaverine HCL (80mg):
An antispasmodic that inhibits phosphodiesterase-IV enzyme, leading to smooth muscle relaxation and pain relief.
⭐ Mefenamic Acid (250mg):
A non-steroidal anti-inflammatory drug (NSAID) that works by reducing prostaglandins, thus lowering pain and inflammation.
📈 Pharmacokinetics & Bioavailability
✔ Absorption: Rapid and complete after oral administration
✔ Onset of Action: Within 30–60 minutes
✔ Duration: Long-lasting relief up to 6 hours
✔ Bioavailability: High oral bioavailability
✔ Excretion: Mainly through urine
🩺 Indications & Uses
🚑 Drotaflam-MF Tablets are used in the management of:
Menstrual cramps (Dysmenorrhea)
Abdominal pain & colicky pain
Gastrointestinal spasms
Renal colic
Post-operative pain
Musculoskeletal cramps
Painful urination (due to UTI or stones)
💊 Dosage & Administration
📌 Adults:
1 tablet two to three times daily, or as directed by the physician.
📌 Administration Tips:
✔ Take with food to avoid gastric discomfort
✔ Swallow whole with water
✔ Do not exceed the recommended dose
🚫 Contraindications
Hypersensitivity to Drotaverine or Mefenamic Acid
Active peptic ulcer
Severe renal or hepatic impairment
Bleeding disorders
Pregnancy (especially third trimester)
⚠️ Warnings & Precautions
⚠️ Use cautiously in:
✔ More than 65 patients
✔ Patients with asthma or gastrointestinal conditions
✔ Individuals with liver or kidney dysfunction
Avoid alcohol while on this medication to reduce stomach irritation.
❗ Adverse Effects
✔ Common: Nausea, vomiting, dizziness, abdominal discomfort
✔ Rare: Allergic reactions, gastrointestinal bleeding, skin rash
Seek immediate medical attention in case of severe allergic symptoms.
💥 Drug Interactions
Avoid concurrent use with other NSAIDs
May enhance effect of anticoagulants like warfarin
Use caution with antiplatelet agents and corticosteroids
📦 Storage Conditions
✔ Store below 25°C
✔ Keep in a cool, dry place away from direct sunlight
✔ Keep out of reach of children
🏁 Conclusion
Drotaflam-MF Tablets offer rapid and effective relief from a variety of spasmodic and inflammatory pain conditions. Trusted by healthcare providers for its dual-action formula, it is ideal for pain management in women’s health and gastrointestinal care.
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📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
