Cefpodoxime Proxetil

Drug class: Cephalosporin antibiotics

• Cefpodoxime proxetil is a semi-synthetic, oral third generation cephalosporin with a broad spectrum of antibacterial activity.

• The drug has in vitro activity against many common Gram-positive and Gram-negative pathogens associated with common paediatric infections, (GI tract disturbances and skin rashes). 

• Well tolerated and demonstrates good bacteriological and clinical efficacy in paediatric patients, with adverse events that are consistent with those reported for other oral cephalosporins.¹

• The drug is available for use as a prodrug-Cefpodoxime proxetil, which is absorbed readily from the gut.

• It reaches adequate levels exceeding the Minimal Inhibitory Concentration in most of the body fluids.

• It is excreted by kidneys, unchanged. The dose needs adjustment in compromised renal function.