Minova Life Science

Minova life sciences - Pharmaceutical company

Histacold-XT Suspension



Each 5ml contains : Chlorpheniramine Maleate IP 2mg +Phenylephrine Hydrochloride  IP 5mg +Paracetamol IP 250mg

Histacold-XT Suspension


Phenylephrine HCl

Drug Class: Sympathomimetic agent/ decongestant

  • Phenylephrine is a direct-acting sympathomimetic amine that functions as an alpha-1 adrenergic agonist.
  • Phenylephrine is a sympathomimetic primarily used as a systemic nasal decongestant. 

Alleviates blocked or stuffy nose:

  • Responsible for the activation of postjunctional alpha-adrenergic receptors in the nasal mucosa by,
    • Distinct binding of the sympathomimetic agent to the binding site of the receptor, or 
    • By the enhanced release of norepinephrine leads to vasoconstriction.

Chlorpheniramine Maleate

Drug Class: Antihistamines

  • Also known as chlorphenamine (CPM), is a potent alkylamine first-generation H1 antihistamine.
  • One of the most often recommended and used 1st generation, antihistaminic agents. 

Anti-allergic and anti-inflammatory action of CPM: 

  • It competitively binds to the H1 receptors of the vascular tunica medius in the nasal mucosa to prevent the histamine vasoreactive response. 
  • Its antihistaminic action is translated to its anti-allergic & anti-inflammatory action in the nasal mucosa. 
  • Its anti-cholinergic action is responsible for the decrease in nasal discharge, which is infective, hence it controls the symptoms of Allergic Rhinitis.

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