Cilnidipine

AL-N type calcium channel blocker that lowers blood pressure without eliciting unfavorable side effects.

o Regulates cellular growth & produces 10 times more potent coronary vasodilator action compared with other CCBS.

Telmisartan

o An effective antihypertensive agent with tolerability profile similar to placebo.

o Produces greater reductions in both systolic and diastolic blood pressure in comparison to losartan.

Combination efficacy:

> More effective in reducing BP without affecting glucose homeostasis than either drug in monotherapy

> Exhibits additive protective effects on renal and cardiac organs. The 2014-

> Decreases plasma aldosterone concentrations and pulse wave velocity for preventing vascular complications