🔬 Introduction
Perocef-SB 1.5 Injection is a broad-spectrum antibiotic that combines Cefoperazone, a third-generation cephalosporin, with Sulbactam, a beta-lactamase inhibitor. This combination is highly effective against drug-resistant bacterial infections, making it a preferred choice in critical care settings.
⚕️ Pharmacokinetics & Bioavailability
✔ Bioavailability: 100% (IV administration)
✔ Peak Plasma Concentration: Within 1 hour of IV infusion
✔ Protein Binding: Cefoperazone – 82-93%, Sulbactam – 38%
✔ Half-life: Cefoperazone – ~2 hours, Sulbactam – ~1 hour
✔ Excretion: Primarily via urine (~75%) and bile (~20%)
🦠 Indications & Uses
🚑 Perocef-SB 1.5 Injection is prescribed for:
✔ Severe Respiratory Tract Infections (Pneumonia, Bronchitis)
✔ Complicated Urinary Tract Infections (UTIs)
✔ Intra-Abdominal Infections (Peritonitis, Appendicitis)
✔ Bacterial Meningitis
✔ Septicemia & Bloodstream Infections
✔ Skin & Soft Tissue Infections
✔ Gynecological Infections (PID, Endometritis)
💉 Dosage & Administration
✔ Adult Dose: 1.5 g every 12 hours or as prescribed
✔ Severe Infections: Dose may be increased to 3 g per day
✔ Pediatric Dose: Adjusted based on body weight
✔ Route: Intravenous (IV) or Intramuscular (IM) administration
📌 Administration Guidelines:
- Administer IV infusion over 15-30 minutes
- Can be given deep IM injection for mild infections
- Dose adjustments may be required for patients with renal or hepatic impairment
⚙️ Mechanism of Action
✔ Cefoperazone: Inhibits bacterial cell wall synthesis, leading to bacterial cell death (bactericidal effect)
✔ Sulbactam: Inhibits beta-lactamase enzymes, enhancing the effectiveness of Cefoperazone
✔ Broad-Spectrum Action: Effective against Gram-positive, Gram-negative, and anaerobic bacteria
⚠️ Warnings & Precautions
❌ Renal & Liver Dysfunction: Dose adjustment required
❌ Hypersensitivity: Avoid in patients allergic to cephalosporins
❌ Bleeding Risk: Cefoperazone may affect coagulation, monitor INR levels
❌ Superinfection Risk: Prolonged use may lead to secondary infections
🚨 Adverse Effects
✔ Common: Diarrhea, nausea, vomiting, rash, headache
✔ Serious: Allergic reactions, Clostridium difficile infection, liver dysfunction
⚡ Drug Interactions
⚡ Alcohol (Disulfiram-like Reaction): Avoid alcohol consumption during and after treatment
⚡ Anticoagulants (Warfarin): Increased bleeding risk
⚡ Loop Diuretics (Furosemide): May increase nephrotoxicity
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 Use reconstituted solution immediately or within the recommended time
🏆 Conclusion
Perocef-SB 1.5 Injection (Cefoperazone 1000 mg + Sulbactam 500 mg) is an effective broad-spectrum antibiotic used for severe bacterial infections. With its dual-action formula, it offers superior efficacy against resistant bacteria, making it an essential choice in hospital settings.
✅ Trusted Pharmaceutical Company in India
Since 2007, we have been at the forefront of scientific research and development, consistently delivering breakthrough medicines and therapies that address critical medical challenges. Our experienced team of experts works tirelessly to ensure that our products meet the highest standards of efficacy, safety, and compliance.
🚀 Perocef-SB – Advanced Broad-Spectrum Antibiotic for Severe Infections! 💊💪
📞 Contact Us
📞 Phone: +91-9845329972
📧 Email: info@minovalifesciences.com
🌐 Website: Minova Life Sciences
